ABSTRACT
There is no consensus about the relationships between chorioamnionitis and 3 pulmonary outcomes of concern for preterm infants:respiratory distress syndrome,pneumonia/sepsis,and bronchopulmonary dysplasia.Intrauterine infection increases the risk of neonatal infection including sepsis/pneumonia,also increases the incidence of bronchopulmonary dysplasia,but may reduce the incidence and severity of respiratory distress syndrome.In recent years,translational research with various animal models has been helpful to answer basic questions about the effect of antenatal inflammation on maturation and development of the fetal lung and immune system.Although the mechanisms are not entirely clear,chorioamnionitis predisposes infants to premature birth,neonatal sepsis,and other adverse outcomes.In this article,we reviewed the relationship of intrauterine infection and neonatal pulmonary morbidity.